Organic nitrogen-selective detector used in gas-chromatographic determination of some anticonvulsant and barbiturate drugs in plasma and tissues.

The specific nitrogen flame-ionization detector was used for the rapid simultaneous determination of eight anticonvulsant drugs and one drug metabolite in plasma and for three of the drugs in tissues. The system of analysis allows the occasional rapid estimation of barbiturate in plasma. No derivative formation is required and the whole range of drugs can be determined in a single diethyl ether extract of plasma in about 20 mm.